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Anti-Notch1 Recombinant Rabbit Monoclonal Antibody

应用范围: WB, IHC-P, IHC-F, ICC/IF, FC
产品类型: 兔单抗
保存温度: -20℃
产地: YOBIBIO
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Basic Information:

UniProt ID: P46531

Calculated Mol Weight: 273 kDa

Host: Rabbit

Observed Mol Weight: 125 kDa

Clonality: Monoclonal

Reactivity: Human, Mouse

Source: Recombinant Rabbit mAb

Applications: WB, IHC-P, IHC-F, ICC/IF, FC

Isotype: Rabbit IgG

Purification: Affinity-chromatography

Modification: Unmodified

Immunogen: A synthesized peptide

Aliases: NOTC1, NOTCH1, TAN1, hN1, neurogenic locus notch homolog protein 1, neurogenic locus notch homolog protein 1 precursor

Recommended Dilutions: 

WB 1:1000-1:2000

 

IHC-P 1:100-1:200

 

IHC-F 1:50-1:200

 

ICC/IF 1:50-1:200

 

FC 1:20-1:100

Storage: Rabbit IgG in 10mM phosphate buffered saline, pH7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol. Store at +4 short term. Store at -20 long term. Avoid repeated freeze-thaw cycle.

Background: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. 


Western blot analysis of extracts of HEK293 lysate ,using NOTCH1 antibody.

For Research Use Only. Not for Use in Diagnostic Procedures. 

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保存温度:-20℃
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