Basic Information:

Storage: Rabbit IgG in 10mM phosphate buffered saline, pH7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol. Store at +4℃ short term. Store at -20℃ long term. Avoid repeated freeze-thaw cycle.

Background: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery.  

Western blot analysis of p38 MAPK expression in (1) HeLa cell lysate; (2) NIH/3T3cell lysate; (3) PC-12 cell lysate.

For Research Use Only. Not for Use in Diagnostic Procedures.