Basic Information:

Storage: Rabbit IgG in 10mM phosphate buffered saline, pH7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol. Store at +4℃ short term. Store at -20℃ long term. Avoid repeated freeze-thaw cycle.

Background: The tumor suppressor protein p21 Waf1/Cip1 acts as an inhibitor of cell cycle progression. It functions in stoichiometric relationships forming heterotrimeric complexes with cyclins and cyclin-dependent kinases. In association with CDK2 complexes, it serves to inhibit kinase activity and block progression through G1/S. However, p21 may also enhance assembly and activity in complexes of CDK4 or CDK6 and cyclin D.

For Research Use Only. Not for Use in Diagnostic Procedures.